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KMID : 1134820190480070777
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Journal of the Korean Society of Food Science and Nutrition
2019 Volume.48 No. 7 p.777 ~ p.782
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Whitening Effects of Diospyros kaki Core Ethanol Extract
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Byun Eui-Baek
Min Hee-Suk
Kim Min-Jin
Kim Soon-Jung
Park Won-Jeong
Song Ha-Yeon
Han Jeong-Moo
Kim Kwang-Wook
Byun Eui-Hong
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Abstract
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This study examined the whitening effect of a Diospyros kaki core ethanol extract (DCE). DCE was used to evaluate its inhibitory effects on tyrosinase and melanin synthesis. The mushroom tyrosinase inhibitory activity of DCE increased in a dose dependent fashion. DCE treatment did not exert cytotoxicity at doses ranging from 62.5 to 1,000 μg/mL in B16F10 melanoma cells. Treatment of 3-isobutyl-1-methylxanthine strongly induced melanin synthesis (518.18±9.1%) as compared with the control group (100%), while the DCE-treated group showed effective inhibition of melanin synthesis (500 and 1,000 μg/mL, 222.73±31.8% and 177.27±4.5%, respectively). The anti-melanogenic effects of DCE were mediated by the regulation of melanogenesis-related proteins, including cAMP response element-binding protein, microphthalmia-associated transcription factor, tyrosinase, tyrosinase-related protein (TRP)-1, and TRP-2. Therefore, these results suggest that DCE has a whitening effect, and it could be developed as a whitening ingredient in cosmetics.
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KEYWORD
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Diospyros kaki core, whitening effects, B16F10 melanoma cell
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